Also on the bill are Yeah Yeah Yeahs, Band of Horses and Vampire Weekend with the 2013 festival shaping up to be one of the biggest yet.
The announcement comes after much speculation, especially following a series of fake Big Day Out posters that were circulated online recently.
Here’s the lineup:
Red Hot Chili Peppers, The Killers, Yeah Yeah Yeahs, Vampire Weekend, Band Of Horses, The Bloody Beetroots Live, Kaskade, Animal Collective, B.o.B, Sleigh Bells, Foals, Alabama Shakes, 360, Crystal Castles, Pretty Lights, Off!, Grinspoon, Against Me!, Nicky Romero, Morgan Page, Gary Clark Jr, Every Time I Die, Delta Spirit, Childish Gambino, Me, Hunting Grounds, JEFF The Brotherhood, Death Grips, Adventure Club, Jagwar Ma, House Vs Hurricane, Avalanche City, Toucan, Helena, Nina Las Vegas and Sampology
What do you make of the lineup? Who are you most excited to see? Join the conversation by leaving a comment below or by sending a tweet to @lukehgomes or @benpeck92 with the hashtag: #bdolineup. You can also comment on our Facebook wall.